Gene Description

Symbol:  HLA-B

Gene:  major histocompatibility complex, class 1, B

Chromosome:  6

Allele:  2705

Background Strain:  Lewis

Strain Development:  This strain was made by pronuclear injection into Lewis embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. Founder 133-1 was selected and carrier animals from this founder were mated and bred to homozygosity. The strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center in 2002. The strain has been maintained by sibling mating.

Other Strain Names:  133-1

Summary of Phenotype

The published phenotype of this rat model consists of arthritis and inflammatory colitis that develops in homozygous rats around 8 months of age. Orchitis develops in both the heterozygous and homozygous males at an early age. Homozygous male rats are sterile by 4 months of age.

Baseline phenotyping including gross and histomorphologic examination, hematology, clinical chemistry and behavioral analysis will be performed on this rat strain in the near future. This baseline phenotype information will be posted on this website as it is completed.

Summary - Gross Findings

Bilateral testicular atrophy was found grossly in 1/4 of the 7-8 month old hemizygous males and 1/4 7-8 month old homozygous males. Bilateral testicular abscesses were found in 2/4 7-8 month old homozygous males, 2/2 4 month old homozygous males, and 1/4 7-8 month old hemizygous males. One of the testicular abscesses was cultured aerobically and anaerobically. There was no bacterial growth. Unilateral testicular atrophy was found in 1/4 7-8 month old hemizygous males. An abscess on the right testicle and atrophy of the other testicle was found in 1/4 7-8 month old homozygous males.
Bilateral epidydimal abscesses were found in 2/4 7-8 month old homozygous males and 2/2 4 month old homozygous males. Unilateral epidydimal abscesses were found in 2/4 7-8 month old hemizygous mutant males and 1/4 7-8 month old homozygous mutant males. An abscessed left coagulating gland was found in 1/4 7-8 month old hemizygous males. An abscessed prostate was found in 1/4 7-8 month old hemizygous males.

Phenotypic Abnormalities - Gross Findings
LEW-Tg(HLA-B*2705m1,B2M)133-1Trg (RRRC:0043)

Finding	Sex	Age	# Affected	Image(s)
Abscess in prostate	M	7-8 month	1/4 hemi
Bilateral testicular abscesses	M	7-8 month	2/4 homo
Bilateral testicular abscesses	M	4 month	2/2 homo
Bilateral epididymal abscess	M	7-8 month	2/4 homo
Bilateral epidymal abscess	M	4 month	2/2 homo

Click on image for larger view.

Organ/Body Weights

	7m hemiM1	7m hemiM2	7-8mhomoM1	7m hemiM3
adrenal	.0455	.0483	.0413	.0476
body weight	507	533	513	513
heart	1.5372	1.4303	1.4303	1.901
kidney	1.8152	1.8905	1.7537	1.8394
liver	19.4585	21.2341	16.7784	20.6706
ovary
spleen	.7205	.7785	.8456	.9182
testicle	.6678	1.1273	not done	not done
	7m hemiM4	7-8mhemiF1	7-8mhemiF2	7-8mhemi F2
adrenal	not done	.0704	.0548	.0558
body weight	503	283	308	289
heart	not done	.9931	.9564	1.0303
kidney	not done	1.0759	1.016	1.2422
liver	not done	12.4357	11.266	11.641
ovary		.0374	.208	.0392
spleen	not done	.4616	.4537	.5546
testicle	not done
	4m homoM1	4mhomoM2	7mcontrolM1	7mcontrolF1
adrenal	.0473	.0453	.0447	.0514
body weight	362	365	518	292
heart	1.1842	1.2363	1.4526	1.0134
kidney	1.3889	1.4123	1.8007	.9928
liver	13.9364	13.1511	18.4933	9.7901
ovary				.0431
spleen	.9716	.9108	.7574	.5336
testicle	not done	not done	not done
	8mcontrolM1	7-8mhomoM2	7-8mhomoF1	8mcontrolF1
adrenal	.0577	.0379	.0523	.0733
body weight	556.9	625.8	393.3	315.45
heart	1.6947	1.5976	1.1079	1.165
kidney	2.0361	1.9785	1.1859	1.066
liver	22.514	21.5888	11.5061	11.613
ovary			.0225	.0706
spleen	2.2130	not done	.4992	.5324
testicle	2.213	not done
	8mcontrolF2	8mcontrolF3	7-8mhomoM3	7-8mhomoF1
adrenal	.0451	.0652	.0356	.488
body weight	287.16	286.6	437	259
heart	1.112	1.0305	1.2882	.7814
kidney	.9453	1.0478	1.753	1.019
liver	9.3866	10.7365	17.79	10.178
ovary	.0355	.0467		.0518
spleen	.5432	.5096	.7310	.4475
testicle			not done
	7-8mhomoF2	7-8mhomoM4	7-8mhomoF3	7mcontolM1
adrenal	.0478	.0438	.0545	.0430
body weight	261	433	276	452
heart	.8276	1.174	.8790	1.359
kidney	.989	1.5783	1.129	1.730
liver	10.2663	13.289	11.45	17.456
ovary	.0577		.391
spleen	.4523	.692	.4562	.6234
testicle		not done		1.447
	7mcontolM	7-8mhemiF4	2mhemiM1	2mhemiM2
adrenal	.0454	not done	.0407	.0378
body weight	438	262.5	195	248
heart	1.213	not done	.8132	1.0490
kidney	1.626	not done	.09597	1.1215
liver	15.411	not done	9.4872	11.8112
ovary		not done
spleen	.956	not done	.4605	.5821
testicle	1.509		1.4608	1.284
	2mhomoM1	2mhomoM2	2mhomoM3	2mhomoM4
adrenal	.0337	.0364	.0299	.0365
body weight	205	217	198	230
heart	.7572	.812	.7643	.8828
kidney	.9955	1.054	.889	.9706
liver	10.9414	10.515	8.7591	10.165
ovary
spleen	.5177	.5300	.5166	.4985
testicle	1.0850	1.14	1.0667	1.167
	2mhomoF1	2mhomoF2	2mhomoF3	2mhomoF4
adrenal	.0323	.0337	.0458	.0361
body weight	141	118	139	135
heart	.513	.5443	.5490	.5770
kidney	.675	.5937	.6392	.6614
liver	6.448	5.2964	6.0329	6.5325
ovary	.244	.0269	.0291	.0370
spleen	.3270	.3508	.3284	.3334
testicle
	2mcontrolF1	2mcontrolF2	2mcontrolF3	2mcontrolM1
adrenal	.0489	.0433	.0676	.0336
body weight	141	145	154	201
heart	.6023	.6695	.6606	.7959
kidney	.7127	.7340	.7759	.923
liver	6.8981	7.1881	7.0728	9.7944
ovary	.0391	.0362	.0535
spleen	.3376	.3780	.3504	.4721
testicle				.9560
	2mcontrolM2	2mcontrolM3	2mcontrolM4	2mhemiM1
adrenal	.0374	.0308	.0481	.0409
body weight	213	192	205	261
heart	.857	.8135	.7528	1.076
kidney	1.012	.9526	.9657	1.284
liver	9.97	9.3350	9.1242	13.271
ovary
spleen	.4886	.4756	.486	.569
testicle	1.0998	.9699	1.0390	1.320
	2mhemiM2	2mhemiF1	2mhemiF2	2mhemiF3
adrenal	.0435		.0498	.0399
body weight	246		161	169
heart	.9611		.6989	.710
kidney	1.1932		.7702	.741
liver	12.5363		7.6403	7.632
ovary			.0518	.0407
spleen	.5141		.3772	.411
testicle	1.3179
	2mhemiF4	2mcontrolF4	7-8mhomoF4
adrenal	.0500	.0628	.0677
body weight	178	175	284
heart	.708	.7212	1.0027
kidney	.7687	.7518	1.0267
liver	8.353	7.4682	11.7403
ovary	.0393	.0392	.0408
spleen	.3917	.3835	.4542
testicle

Summary - Histology

Sterile testicular abscesses that ranged form mild to severe were found histologically in 4/4 7-8 month old homozygous mutants, 4/4 7-8 month old hemizygous mutants and 2/2 4 month old homozygous mutants. Epididymal abscesses were found histologically in 4/4 7-8month old homozygous mutants, 4/4 7-8 month old hemizygous mutants and 2/2 4 month old homozygous mutants.

Phenotypic Abnormalities - Histology
LEW-Tg(HLA-B*2705m1,B2M)133-1Trg (RRRC:0043)

Organ	Lesion	Sex	Age	# Affected	Image(s)
testes	severe abscess	M	7-8m	1/4 hemi
epididymis	severe abscess	M	7-8m	1/4 hemi
testes	mild abscess	M	7-8m	2/4 hemi
epididymis	mild abscess	M	7-8m	2/4 hemi
epididymis	moderate abscess	M	7-8m	1/4 hemi
testes	moderate abscess	M	7-8m	1/4 hemi
testes	severe abscess	M	4m	2/2 homo
testes	severe abscess	M	7-8m	3/4 homo
epidydmis	severe abscess	M	7-8m	2/4 homo
epididymis	severe abscess	M	4m	2/2 homo
testes	mild abscess	M	7-8m	1/4 homo
epididymis	mild abscess	M	7-8 m	2/4 homo

Click on lesion for full description. Click on image for larger view.

Complete Data - Histology

(Click on lesion for full description.)

	7m hemiM1	7m hemiM2	7-8mhomoM1	7m hemiM3
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-	-	-	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-		-	-
cerebrum
no lesions	-		-	-
cervix
no lesions
clitoral gland
no lesions
coagulating gland
no lesions	-	-	-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess	+	-	+	-
mild abscess	-	+	-	-
moderate abscess	-	-	-	+
eye
no lesions	-	-	-	-
femur
no lesions	-
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	+	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	+	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	+	-	-	-
peribronchiolar lymphoid infiltrates	+	+	+	-
peribronchiolar lymphoid hyperplasia	+	+	-	-
mild multifocal subpleural lymphoid infiltrate	+	-	+	-
alveolar histiocytosis	+	-	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	+	-	-
perivascular lymphoid infiltrates	-	+	+	+
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	-	-	-	+
perivascular lymphoid infiltrate	-	-	-	-
mammary gland
no lesions
mandibular lymph node(s)
occasional pigmented macrophages	-	+	+	+
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	-	+
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	-	-	+
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-
preputial glands
no lesions	-	-	-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	-	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	+	-	+	-
mild abscess	-	+	-	-
moderate abscess	-	-	-	+
thymus
focal to multifocal areas of hemorrhage	-		-	-
occasional pigmented macrophages	-		-	+
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	+	+	-	+
diffuse submucosal lymphoid infiltrates	-		-	-
mucosal and submucosal neutrophilic infiltrates	-		-	-
focal amorphous eosinophilic accumulations	-		-	-
urethra
coagulum accumulation	+	+	-	+
mild submucosal lymphoid infiltrates	-	-	-	+
occasional luminal neutrophil	-	-	-	+
urinary bladder
coagulum accumulation	+		+	-
occasional luminal RBC	-		+	+
occasional luminal neutrophil	-		-	+
mild submucosal lymphoid infiltrates	-		-	-
uterus
no lesions
vagina
no lesions
vesicular gland
no lesions	-	-	-	-
	7m hemiM4	7-8mhemiF1	7-8mhemiF2	7-8mhemi F2
adrenal gland(s)
no lesions		-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions		-		-
brown fat
no lesions		-	-	-
bulbourethral gland
no lesions
cecum
lymphoid hyperplasia	+	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions		-	-	-
cerebrum
no lesions		-	-	-
cervix
no lesions		-	-	-
clitoral gland
no lesions		-	-	-
coagulating gland
no lesions
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates		-	-	-
epididymis
severe abscess	-
mild abscess	+
moderate abscess	-
eye
no lesions		-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates		-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia		-	-	-
mild diffuse increase in lymphocytes		-	-	-
kidney
perivascular lymphoid infiltrate		-	-	-
tubular regeneration		-	-	-
mild unilateral hydronephrosis		-	-	-
mild focal epithelial hyperplasia		-	-	-
bilateral pyelitis		-	-	-
tubular vacuolation		-	-	-
tubular pigment deposits		-	-	-
nephrocalcinosis		-	-	-
peripelvic lymphoid infiltrate		-	+	+
lacrimal gland, exorbital
no lesions		-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate		-	-	-
peribronchiolar lymphoid infiltrates		+	-	+
peribronchiolar lymphoid hyperplasia		+	-	+
mild multifocal subpleural lymphoid infiltrate		-	+	-
alveolar histiocytosis		-	-	-
mild scattered alveolar macrophages		+	+	+
mild multifocal lymphoid infiltrates		-	-	-
subpleural alveolar histiocytosis		-	-	-
focal subendothelial mineralization		-	-	-
mild focal aggregate of mast cells		-	-	-
scattered pigment laden macrophages		-	-	-
perivascular lymphoid infiltrates		-	-	+
mild focal neutrophilic aggregate		-	-	-
perivascular neutrophilic infiltrates		-	-	-
focal accumulation of eosinophilic crystals		-	-	-
focal interstitial pneumonia		-	-	-
multifocal peribronchiolar lymphoid hyperplasia		-	+	+
perivascular lymphoid infiltrate		-	-	-
mammary gland
no lesions		-	-	-
mandibular lymph node(s)
occasional pigmented macrophages		+	-	+
occasional neutrophils		-	-	-
mild medullary plasmacytosis		-	+	-
mesenteric lymph node
mild medullary plasmacytosis		-	-	-
occasional pigmented macrophages		-	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions		-	-	-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions				-
parotid salivary glands
no lesions		-	-	-
pituitary gland
no lesions		-	-	-
preputial glands
no lesions	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions		-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions		-	-	-
spleen
hemosiderosis	-	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions		-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions		-	-	-
testes
severe abscess	-
mild abscess	+
moderate abscess	-
thymus
focal to multifocal areas of hemorrhage			-	-
occasional pigmented macrophages			-	-
thyroid gland
no lesions		-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates		-	+	+
diffuse submucosal lymphoid infiltrates		-	-	-
mucosal and submucosal neutrophilic infiltrates		-	-	-
focal amorphous eosinophilic accumulations		-	-	-
urethra
coagulum accumulation	+
mild submucosal lymphoid infiltrates	-
occasional luminal neutrophil	-
urinary bladder
coagulum accumulation		-	-	-
occasional luminal RBC		-	-	-
occasional luminal neutrophil		-	-	-
mild submucosal lymphoid infiltrates		-	-	-
uterus
no lesions		-	-	-
vagina
no lesions		-	-	-
vesicular gland
no lesions
	4m homoM1	4mhomoM2	7mcontrolM1	7mcontrolF1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-	-	-
cecum
lymphoid hyperplasia	+	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-		-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions
clitoral gland
no lesions
coagulating gland
no lesions	-	-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	+	-	-
epididymis
severe abscess	+	+	-
mild abscess	-	-	-
moderate abscess	-	-	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	+	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	+	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	-	+	-
peribronchiolar lymphoid infiltrates	+	-	+	+
peribronchiolar lymphoid hyperplasia	-	+	-	-
mild multifocal subpleural lymphoid infiltrate	-	+	+	+
alveolar histiocytosis	-	-	-	-
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	+	-	-
subpleural alveolar histiocytosis	-	-	-	+
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	+	-	+
perivascular lymphoid infiltrates	+	+	-	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	-	-	-
perivascular lymphoid infiltrate	+	-	-	-
mammary gland
no lesions
mandibular lymph node(s)
occasional pigmented macrophages	-	+	-	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	+	+
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	-	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-	-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	-	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	+	+	-
mild abscess	-	-	-
moderate abscess	-	-	-
thymus
focal to multifocal areas of hemorrhage	-	-	+	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	-	+
diffuse submucosal lymphoid infiltrates	-	+	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	+	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation	-	+	+
mild submucosal lymphoid infiltrates	-	+	-
occasional luminal neutrophil	-	+	-
urinary bladder
coagulum accumulation	-	-	-	-
occasional luminal RBC	-	-	-	-
occasional luminal neutrophil	-	-	+	-
mild submucosal lymphoid infiltrates	+	-	-	-
uterus
no lesions
vagina
no lesions
vesicular gland
no lesions	-	-	-
	8mcontrolM1	7-8mhomoM2	7-8mhomoF1	8mcontrolF1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions			-	-
clitoral gland
no lesions			-	-
coagulating gland
no lesions	-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	+	-	-
epididymis
severe abscess	-	+
mild abscess	-	-
moderate abscess	-	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	+
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	+
tubular regeneration	-	+	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	+	+	-
peribronchiolar lymphoid infiltrates	+	-	-	+
peribronchiolar lymphoid hyperplasia	+	+	+	-
mild multifocal subpleural lymphoid infiltrate	-	+	-	-
alveolar histiocytosis	-	-	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	+	-	-	-
mild focal aggregate of mast cells	-	-	+	-
scattered pigment laden macrophages	+	+	-	+
perivascular lymphoid infiltrates	+	+	-	+
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	-	-	-	-
perivascular lymphoid infiltrate	-	-	+	-
mammary gland
no lesions			-	-
mandibular lymph node(s)
occasional pigmented macrophages	-	-	+	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	+	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	+	+	+	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions			-	-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	+	-	+
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	-	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	-	+
mild abscess	-	-
moderate abscess	-	-
thymus
focal to multifocal areas of hemorrhage	-	-	-	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	+	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation	-	-
mild submucosal lymphoid infiltrates	-	-
occasional luminal neutrophil	-	-
urinary bladder
coagulum accumulation	+	-		-
occasional luminal RBC	-	-		-
occasional luminal neutrophil	-	-		-
mild submucosal lymphoid infiltrates	-	-		-
uterus
no lesions			-	-
vagina
no lesions			-	-
vesicular gland
no lesions	-	-
	8mcontrolF2	8mcontrolF3	7-8mhomoM3	7-8mhomoF1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions			-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions	-	-		-
clitoral gland
no lesions	-	-		-
coagulating gland
no lesions			-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess			-
mild abscess			+
moderate abscess			-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	+	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	+	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	-	-	-
peribronchiolar lymphoid infiltrates	-	-	+	-
peribronchiolar lymphoid hyperplasia	+	+	-	+
mild multifocal subpleural lymphoid infiltrate	-	+	+	-
alveolar histiocytosis	-	-	-	-
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	-	+	+	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	+	+	-	+
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	-	-	+	+
perivascular lymphoid infiltrate	-	-	-	-
mammary gland
no lesions	-	-		-
mandibular lymph node(s)
occasional pigmented macrophages	-	-	-	+
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	-	-
mesenteric lymph node
mild medullary plasmacytosis	+	-	-	-
occasional pigmented macrophages	-	+	-	+
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions	-	-		-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions			-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess			-
mild abscess			+
moderate abscess			-
thymus
focal to multifocal areas of hemorrhage	+	+	-	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	+	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation			-
mild submucosal lymphoid infiltrates			-
occasional luminal neutrophil			-
urinary bladder
coagulum accumulation	-	-	-	-
occasional luminal RBC	-	-	-	-
occasional luminal neutrophil	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
uterus
no lesions	-	-		-
vagina
no lesions	-	-		-
vesicular gland
no lesions			-
	7-8mhomoF2	7-8mhomoM4	7-8mhomoF3	7mcontolM1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions		-		-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions	-		-
clitoral gland
no lesions	-		-
coagulating gland
no lesions		-		-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess		-		-
mild abscess		+		-
moderate abscess		-		-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	+
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	+	-	-
tubular vacuolation	-	-	+	-
tubular pigment deposits	-	-	+	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	+	+	+	-
peribronchiolar lymphoid infiltrates	-	-	-	-
peribronchiolar lymphoid hyperplasia	-	-	-	+
mild multifocal subpleural lymphoid infiltrate	+	-	-	-
alveolar histiocytosis	-	-	-	-
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	-	-	-	+
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	+	-	-	-
perivascular lymphoid infiltrates	-	+	+	+
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	+	+	+
perivascular lymphoid infiltrate	-	-	-	-
mammary gland
no lesions	-		-
mandibular lymph node(s)
occasional pigmented macrophages	+	-	+	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	+	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	+	-	+
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions	-		-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions		-		-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	+
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess		+		-
mild abscess		-		-
moderate abscess		-		-
thymus
focal to multifocal areas of hemorrhage	-	-	+	-
occasional pigmented macrophages	-	+	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	+	-	-	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation		-		-
mild submucosal lymphoid infiltrates		-		-
occasional luminal neutrophil		-		-
urinary bladder
coagulum accumulation	-		-	+
occasional luminal RBC	-		-	-
occasional luminal neutrophil	-		-	-
mild submucosal lymphoid infiltrates	-		-	+
uterus
no lesions	-		-
vagina
no lesions	-		-
vesicular gland
no lesions		-		-
	7mcontolM	7-8mhemiF4	2mhemiM1	2mhemiM2
adrenal gland(s)
no lesions	-		-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-		-	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-		-	-
cerebrum
no lesions	-		-	-
cervix
no lesions
clitoral gland
no lesions		-
coagulating gland
no lesions	-		-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	+
epididymis
severe abscess	+		-	-
mild abscess	-		-	-
moderate abscess	-		-	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	+
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	+	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	+	-	+
peribronchiolar lymphoid infiltrates	-	-	-	-
peribronchiolar lymphoid hyperplasia	-	-	-	+
mild multifocal subpleural lymphoid infiltrate	-	-	-	-
alveolar histiocytosis	-	-	-	-
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	+	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	+	+	+	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	+	-	-
perivascular lymphoid infiltrate	-	-	-	+
mammary gland
no lesions		-
mandibular lymph node(s)
occasional pigmented macrophages	+		-	-
occasional neutrophils	-		-	-
mild medullary plasmacytosis	+		-	-
mesenteric lymph node
mild medullary plasmacytosis	-		-	-
occasional pigmented macrophages	+		-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-		-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-		-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	+	+	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-		-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-		-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-		-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	+		-	-
mild abscess	-		-	-
moderate abscess	-		-	-
thymus
focal to multifocal areas of hemorrhage	-		-	-
occasional pigmented macrophages	-		-	-
thyroid gland
no lesions	-		-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-		-	-
diffuse submucosal lymphoid infiltrates	-		-	-
mucosal and submucosal neutrophilic infiltrates	-		-	-
focal amorphous eosinophilic accumulations	-		-	+
urethra
coagulum accumulation	-		-	-
mild submucosal lymphoid infiltrates	-		-	-
occasional luminal neutrophil	-		-	-
urinary bladder
coagulum accumulation	-		-	+
occasional luminal RBC	-		-	-
occasional luminal neutrophil	-		-	-
mild submucosal lymphoid infiltrates	-		-	-
uterus
no lesions
vagina
no lesions
vesicular gland
no lesions	-		-	-
	2mhomoM1	2mhomoM2	2mhomoM3	2mhomoM4
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-	-	-	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions
clitoral gland
no lesions
coagulating gland
no lesions	-	-	-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess	-	-	-	-
mild abscess	-	-	-	-
moderate abscess	-	-	-	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	-	-	-
peribronchiolar lymphoid infiltrates	+	+	-	-
peribronchiolar lymphoid hyperplasia	-	-	+	-
mild multifocal subpleural lymphoid infiltrate	-	-	-	-
alveolar histiocytosis	+	+	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	+	-	-	+
mild focal neutrophilic aggregate	-	+	-	-
perivascular neutrophilic infiltrates	-	-	+	-
focal accumulation of eosinophilic crystals	-	-	+	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	+	-	-
perivascular lymphoid infiltrate	-	-	+	-
mammary gland
no lesions
mandibular lymph node(s)
occasional pigmented macrophages	-	-	-	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	-	-	+
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-	-	-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	+
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	-	-	-	-
mild abscess	-	-	-	-
moderate abscess	-	-	-	-
thymus
focal to multifocal areas of hemorrhage	-	-	-	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	+	-	+
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
occasional luminal neutrophil	-	-	-	-
urinary bladder
coagulum accumulation	+	+	-	-
occasional luminal RBC	-	-	+	+
occasional luminal neutrophil	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
uterus
no lesions
vagina
no lesions
vesicular gland
no lesions	-	-	-	-
	2mhomoF1	2mhomoF2	2mhomoF3	2mhomoF4
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions	-	-	-	-
clitoral gland
no lesions	-	-	-	-
coagulating gland
no lesions
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess
mild abscess
moderate abscess
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	-	-	-
peribronchiolar lymphoid infiltrates	-	+	+	-
peribronchiolar lymphoid hyperplasia	-	-	-	-
mild multifocal subpleural lymphoid infiltrate	+	-	-	+
alveolar histiocytosis	-	+	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	-	-	-	+
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	+	+	-	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	+	-	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	+	-	+
perivascular lymphoid infiltrate	-	-	+	-
mammary gland
no lesions	-	-	-	-
mandibular lymph node(s)
occasional pigmented macrophages	+	-	-	-
occasional neutrophils	-	-	-	+
mild medullary plasmacytosis	-	-	-	+
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	-	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions	-	-	-	-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	+	-	-	-
mild diffuse increase in lymphocytes	+	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess
mild abscess
moderate abscess
thymus
focal to multifocal areas of hemorrhage	-	-		-
occasional pigmented macrophages	-	-		-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	+	+	+	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation
mild submucosal lymphoid infiltrates
occasional luminal neutrophil
urinary bladder
coagulum accumulation	-	-	-	-
occasional luminal RBC	-	-	-	-
occasional luminal neutrophil	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
uterus
no lesions	-	-	-	-
vagina
no lesions	-	-	-	-
vesicular gland
no lesions
	2mcontrolF1	2mcontrolF2	2mcontrolF3	2mcontrolM1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions				-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions	-	-	-
clitoral gland
no lesions	-	-	-
coagulating gland
no lesions				-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess				-
mild abscess				-
moderate abscess				-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	+	-	+	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	+	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	+	-	-
peribronchiolar lymphoid infiltrates	-	-	+	-
peribronchiolar lymphoid hyperplasia	+	-	+	-
mild multifocal subpleural lymphoid infiltrate	+	-	+	-
alveolar histiocytosis	-	+	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	+	-	-	-
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	-	-	-	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	+	+	+	+
focal accumulation of eosinophilic crystals	-	-	-	+
focal interstitial pneumonia	-	+	-	+
multifocal peribronchiolar lymphoid hyperplasia	-	+	-	-
perivascular lymphoid infiltrate	-	+	-	+
mammary gland
no lesions	-	-	-
mandibular lymph node(s)
occasional pigmented macrophages	-	-	-	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	+	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	+	-	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions	-	-	-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions				-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess				-
mild abscess				-
moderate abscess				-
thymus
focal to multifocal areas of hemorrhage	-	-	-	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	-	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation				-
mild submucosal lymphoid infiltrates				-
occasional luminal neutrophil				-
urinary bladder
coagulum accumulation	-	-	-
occasional luminal RBC	+	-	+
occasional luminal neutrophil	-	-	-
mild submucosal lymphoid infiltrates	-	-	-
uterus
no lesions	-	-	-
vagina
no lesions	-	-	-
vesicular gland
no lesions				-
	2mcontrolM2	2mcontrolM3	2mcontrolM4	2mhemiM1
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-	-	-	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions
clitoral gland
no lesions
coagulating gland
no lesions	-	-	-	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess	-	-	-	-
mild abscess	-	-	-	-
moderate abscess	-	-	-	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	+	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	-	-	-
peribronchiolar lymphoid infiltrates	-	-	-	-
peribronchiolar lymphoid hyperplasia	-	-	-	-
mild multifocal subpleural lymphoid infiltrate	+	-	-	-
alveolar histiocytosis	+	-	-	-
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	-	-
subpleural alveolar histiocytosis	+	-	-	-
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	-	-	-	-
perivascular lymphoid infiltrates	-	-	-	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	+	+	+	-
focal accumulation of eosinophilic crystals	-	-	-	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	-	+	-	+
perivascular lymphoid infiltrate	-	+	-	+
mammary gland
no lesions
mandibular lymph node(s)
occasional pigmented macrophages	-	-	-	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	+	+	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	+	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-	-	-	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	-	-	-	-
mild abscess	-	-	-	-
moderate abscess	-	-	-	-
thymus
focal to multifocal areas of hemorrhage	-	-	+	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	-	+
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
occasional luminal neutrophil	-	-	-	-
urinary bladder
coagulum accumulation	+	-	-	-
occasional luminal RBC	-	+	+	+
occasional luminal neutrophil	-	-	-	-
mild submucosal lymphoid infiltrates	-	-	-	-
uterus
no lesions
vagina
no lesions
vesicular gland
no lesions	-	-	-	-
	2mhemiM2	2mhemiF1	2mhemiF2	2mhemiF3
adrenal gland(s)
no lesions	-	-	-	-
aorta
no lesions	-	-	-	-
back skin
no lesions	-	-	-	-
brown fat
no lesions	-	-	-	-
bulbourethral gland
no lesions	-
cecum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
cerebellum
no lesions	-	-	-	-
cerebrum
no lesions	-	-	-	-
cervix
no lesions		-	-	-
clitoral gland
no lesions		-	-	-
coagulating gland
no lesions	-
costrochondral junction
no lesions	-	-	-	-
diaphragm
no lesions	-	-	-	-
distal colon
no lesions	-	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-	-
epididymis
severe abscess	-
mild abscess	-
moderate abscess	-
eye
no lesions	-	-	-	-
femur
no lesions
Harderian gland
no lesions	-	-	-	-
heart
mild increase in lymphoid aggregates	-	-	-	-
ileum
no lesions	-	-	-	-
incisor tooth
no lesions	-	-	-	-
inner ear
no lesions	-	-	-	-
jejunum
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
kidney
perivascular lymphoid infiltrate	-	-	-	-
tubular regeneration	-	-	-	-
mild unilateral hydronephrosis	-	-	-	-
mild focal epithelial hyperplasia	-	-	-	-
bilateral pyelitis	-	-	-	-
tubular vacuolation	-	-	-	-
tubular pigment deposits	-	-	-	-
nephrocalcinosis	-	-	-	-
peripelvic lymphoid infiltrate	-	-	-	-
lacrimal gland, exorbital
no lesions	-	-	-	-
liver
no lesions	-	-	-	-
lung
peribronchiolar lymphoid infiltrate	-	+	-	-
peribronchiolar lymphoid infiltrates	-	-	-	-
peribronchiolar lymphoid hyperplasia	-	+	-	+
mild multifocal subpleural lymphoid infiltrate	+	-	+	-
alveolar histiocytosis	-	-	-	+
mild scattered alveolar macrophages	+	+	+	+
mild multifocal lymphoid infiltrates	-	-	+	-
subpleural alveolar histiocytosis	-	-	-	-
focal subendothelial mineralization	-	-	-	-
mild focal aggregate of mast cells	-	-	-	-
scattered pigment laden macrophages	+	-	-	-
perivascular lymphoid infiltrates	+	-	-	-
mild focal neutrophilic aggregate	-	-	-	-
perivascular neutrophilic infiltrates	-	-	-	-
focal accumulation of eosinophilic crystals	-	-	+	-
focal interstitial pneumonia	-	-	-	-
multifocal peribronchiolar lymphoid hyperplasia	-	-	-	-
perivascular lymphoid infiltrate	-	+	+	-
mammary gland
no lesions		-	-	-
mandibular lymph node(s)
occasional pigmented macrophages	+	-	-	-
occasional neutrophils	-	-	-	-
mild medullary plasmacytosis	-	-	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-	-	-
occasional pigmented macrophages	-	-	-	-
molar tooth
no lesions	-	-	-	-
nasal cavity
no lesions	-	-	-	-
ovary
no lesions		-	-	-
pancreas
no lesions	-	-	-	-
parathyroid gland
no lesions	-	-	-	-
parotid salivary glands
no lesions	-	-	-	-
pituitary gland
no lesions	-	-	-	-
preputial glands
no lesions	-
prostate gland
no lesions	-	-	-	-
proximal colon
lymphoid hyperplasia	-	-	-	-
mild diffuse increase in lymphocytes	-	-	-	-
quadriceps muscle
no lesions	-	-	-	-
sciatic nerve
no lesions	-	-	-	-
skin
no lesions	-	-	-	-
spinal cord
no lesions	-	-	-	-
spleen
hemosiderosis	+	+	+	+
sternum-bone marrow
no lesions	-	-	-	-
stifle
no lesions	-	-	-	-
stomach
no lesions	-	-	-	-
sublingual salivary gland
no lesions	-	-	-	-
submand. salivary glands
no lesions	-	-	-	-
tail head skin
no lesions	-	-	-	-
testes
severe abscess	-
mild abscess	-
moderate abscess	-
thymus
focal to multifocal areas of hemorrhage	-	-	-	-
occasional pigmented macrophages	-	-	-	-
thyroid gland
no lesions	-	-	-	-
tongue
no lesions	-	-	-	-
trachea
submucosal lymphoid infiltrates	-	-	-	-
diffuse submucosal lymphoid infiltrates	-	-	-	-
mucosal and submucosal neutrophilic infiltrates	-	-	-	-
focal amorphous eosinophilic accumulations	-	-	-	-
urethra
coagulum accumulation	-
mild submucosal lymphoid infiltrates	-
occasional luminal neutrophil	-
urinary bladder
coagulum accumulation		-	-	-
occasional luminal RBC		+	-	-
occasional luminal neutrophil		-	-	-
mild submucosal lymphoid infiltrates		-	-	-
uterus
no lesions		-	-	-
vagina
no lesions		-	-	-
vesicular gland
no lesions	-
	2mhemiF4	2mcontrolF4	7-8mhomoF4
adrenal gland(s)
no lesions	-	-
aorta
no lesions	-	-
back skin
no lesions	-	-
brown fat
no lesions	-	-
bulbourethral gland
no lesions
cecum
lymphoid hyperplasia	-	-	-
mild diffuse increase in lymphocytes	-	-	+
cerebellum
no lesions	-	-
cerebrum
no lesions	-	-
cervix
no lesions	-	-
clitoral gland
no lesions	-	-
coagulating gland
no lesions
costrochondral junction
no lesions	-	-
diaphragm
no lesions	-	-
distal colon
no lesions	-	-	-
duodenum
mild increase in lymphoid aggregates	-	-	-
epididymis
severe abscess
mild abscess
moderate abscess
eye
no lesions	-	-
femur
no lesions
Harderian gland
no lesions	-	-
heart
mild increase in lymphoid aggregates	-	-	-
ileum
no lesions	-	-
incisor tooth
no lesions	-	-
inner ear
no lesions	-	-
jejunum
lymphoid hyperplasia	-	-	-
mild diffuse increase in lymphocytes	-	-	+
kidney
perivascular lymphoid infiltrate	-	-
tubular regeneration	-	-
mild unilateral hydronephrosis	-	-
mild focal epithelial hyperplasia	-	-
bilateral pyelitis	-	-
tubular vacuolation	-	-
tubular pigment deposits	-	-
nephrocalcinosis	-	-
peripelvic lymphoid infiltrate	-	-
lacrimal gland, exorbital
no lesions	-	-
liver
no lesions	-	-
lung
peribronchiolar lymphoid infiltrate	+	-
peribronchiolar lymphoid infiltrates	-	+
peribronchiolar lymphoid hyperplasia	-	-
mild multifocal subpleural lymphoid infiltrate	-	-
alveolar histiocytosis	-	-
mild scattered alveolar macrophages	+	+
mild multifocal lymphoid infiltrates	-	-
subpleural alveolar histiocytosis	-	+
focal subendothelial mineralization	-	-
mild focal aggregate of mast cells	-	-
scattered pigment laden macrophages	-	+
perivascular lymphoid infiltrates	-	-
mild focal neutrophilic aggregate	-	-
perivascular neutrophilic infiltrates	-	-
focal accumulation of eosinophilic crystals	-	-
focal interstitial pneumonia	-	-
multifocal peribronchiolar lymphoid hyperplasia	+	-
perivascular lymphoid infiltrate	-	-
mammary gland
no lesions	-	-
mandibular lymph node(s)
occasional pigmented macrophages	-	-
occasional neutrophils	-	-
mild medullary plasmacytosis	-	-
mesenteric lymph node
mild medullary plasmacytosis	-	-
occasional pigmented macrophages	-	-
molar tooth
no lesions	-	-
nasal cavity
no lesions	-	-
ovary
no lesions	-	-
pancreas
no lesions	-	-
parathyroid gland
no lesions	-	-
parotid salivary glands
no lesions	-	-
pituitary gland
no lesions	-	-
preputial glands
no lesions
prostate gland
no lesions	-	-
proximal colon
lymphoid hyperplasia	-	+	-
mild diffuse increase in lymphocytes	-	-	+
quadriceps muscle
no lesions	-	-
sciatic nerve
no lesions	-	-
skin
no lesions	-	-
spinal cord
no lesions	-	-
spleen
hemosiderosis	+	+
sternum-bone marrow
no lesions	-	-
stifle
no lesions	-	-	-
stomach
no lesions	-	-	-
sublingual salivary gland
no lesions	-	-
submand. salivary glands
no lesions	-	-
tail head skin
no lesions	-	-
testes
severe abscess
mild abscess
moderate abscess
thymus
focal to multifocal areas of hemorrhage	-	-
occasional pigmented macrophages	-	-
thyroid gland
no lesions	-	-
tongue
no lesions	-	-
trachea
submucosal lymphoid infiltrates	-	+
diffuse submucosal lymphoid infiltrates	-	-
mucosal and submucosal neutrophilic infiltrates	-	-
focal amorphous eosinophilic accumulations	-	-
urethra
coagulum accumulation
mild submucosal lymphoid infiltrates
occasional luminal neutrophil
urinary bladder
coagulum accumulation	-	-
occasional luminal RBC	+	-
occasional luminal neutrophil	-	-
mild submucosal lymphoid infiltrates	-	-
uterus
no lesions	-	-
vagina
no lesions	-	-
vesicular gland
no lesions